![]() COX-IV protein plays an important role in aerobic exercise capacity by regulation of mitochondrial oxiative phosphorylation. And it has been known that the trained individuals showed a higher number of SIRT-3 proteins and mitochondria compared to sedentary individuals. ![]() showed that treadmill running increased the amount of SIRT-3 protein and mitochondria density in the skeletal muscle of the rats. showed that the expression of SIRT-3 was increased in 7-week-old FVB/NJ rats after 6 weeks of wheel-cage exercise. SIRT-1 (silent mating type information regulation 2, homolog 1) is activated by the PGC-1α and recent studies have shown that SIRT-3 (silent mating type information regulation 2, homolog 2) exists in the mitochondria and increases PGC-1α that induce mitochondrial biogenesis by regulating mitochondrial number and substrate utilization.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |